江苏省建湖县健康人群流行性脑脊膜炎血清学调查

目的了解江苏省建湖县健康人群流行性脑脊髓膜炎（流脑）A、C群抗体水平，评价流脑多糖菌苗的接种状况，为制定控制措施提供依据。方法2006、2007年对建湖县的5个乡镇735名健康人的血清，采用酶联免疫吸附试验（ELISA法）检测A、C群流脑IgG抗体水平。结果流脑A群抗体阳性率为78．91％，GMT为1：12．87；流脑C群抗体阳性率为28．84％，GMT为1：2．49。A群与C群抗体阳性率、GMT差异均有统计学意义（χ^2=114．14，P〈0．01；t=18．84，P〈0．01）。流脑A群抗体阳性率，7个年龄组间差异有统计学意义（χ^2=70．79，P〈0．01）；性别差异无统计学意义（χ^2=0．227，P=0．634）；5个地区间差异有统计学意义（χ^2=16．78，P=0．002）；免疫史不同，差异无统计学意义（χ^2=7．98，P=0．092）。流脑C群抗体阳性率，7个年龄组间差异有统计学意义（χ^2=72．48，P〈0．01）；性别差异无统计学意义（χ^2=2．89，P=0．089）；5个地区差异有统计学意义（χ^2=225．85，P〈0．01）；免疫史不同差异有统计学意义（χ^283．98，P〈0．01）。流脑A群、C群的GMT，不同年龄组（F=9．92，P〈0．01；F=18．54，P〈0．01）、不同地区（F=17．468，P〈0．01；F=83．19，P〈0．01）、免疫史差异（F=26．44，P〈0．01；F=20．72，P〈0．01）差异均有统计学意义，性别差异（F=1．306，P=0．254；F=2．401，P=0．122）无统计学意义。结论近期内建湖县不会发生流脑A群流行，存在散发或暴发流脑c群的可能。应继续加强流脑A＋C疫苗的预防接种工作。

Serological Survey on Epidemic Cerebrospinal Meningitis among Healthy Population in Jianhu County of Jiangsu Province

Objective]To explore the antibody level against group A and C of epidemic cerebrospinal meningitis among healthy population in Jianhu county of Jiangsu province, evaluate the vaccination situation of polysaeeharide vaccine, provide scientific basis for making con- trol measures. Methods ] Blood serum sample from healthy population in 5 towns of Jianhu county were collected in 2006 and 2007, and the semgroup A and C specific IgG antibody were tested by enzyme -linked immunosorbent assay （ ELISA}. Results]The antibody positive rate of group A was 78.91% and the GMT was 1 ： 12.87. For group C, the positive rate was 28.84 % and the GMT was 1：2.49. There were significant differences in the positive rate （χ^2 =114. 14, P 〈0.001 ） and GMT（ t =18.84, P 〈0.001 ） between group A and group C. For the antibody positive rate of group A, there were significant differences among 7 age groups （ χ^2 = 70. 79, P 〈 0. 001 ）, 5 area groups（ χ^2 = 16. 78,P =0.002 ））, and there were no significant differences between male and female （χ^2 =0.227, P =0.634 ）, among different immunization history （χ^2 =7.98, P =0.092）. For the antibody positive rate of group C, there were significant differences among 7 age groups （χ^2 = 72.48,P 〈 0.01）, 5 area groups （ χ^2= 225.85, P 〈 0. 01 ）, and different immunization history （χ^2 = 83.98, P 〈 0. 01）, there was no significant differences between male and female （χ^2 =2.89, P =0.089）. There were significant differences in GMT of group A and c among age groups （ F =9.92, P〈0.01; F =18.54, P 〈0.01}, area groups （ F =17.468, P 〈0.01; F =83.19, P 〈0.01）, different immunization history （ F =26.44, P 〈1301; F =20.72, P 〈0.01）, and the difference between male and female was no significant （ F =1.306,P=0.254;F=2.401, P =0. 122}. Conclusion]The outbreak of epidemic cerebrospinal meningitis of group A might not occur, however, the sporadic cases or outbreak of group C might happen. The immunization with vaccine o