牛脾提取肽类对大鼠Masugi肾炎的治疗作用

目的:观察牛脾脏肽类对大鼠Masugi肾炎的治疗作用.方法:将预先制备的兔抗鼠肾毒血清注射入正常大鼠体内,诱导产生Masugi肾炎.在该模型上,牛脾提取肽KZ-36按50μg/kg/d的剂量经腹腔注射给药2周,观察各疗效指标,并设模型对照及氢化可的松阳性对照.结果:KZ-36给药后第1周大鼠24 h尿蛋白排出量明显减少,第2周为5.0 ±4.1 mg,显著低于模型组相应值17.2±14.5 mg(P＜0.01).KZ-36也明显降低血清肌酐水平,减轻肾脏组织的病理损害.结论:牛脾提取肽对大鼠Masugi肾炎有显著疗效,值得进一步研究.

Therapeutic Effects of a Low Molecular Weight Peptide from Cattle Spleen on Masugi Nephritis in Rats

OBJECTIVE: To investigate the therapeutic effects of a low molecular weight peptide KZ-36 from cattle spleen on masugi nephritis in rats. METHODS: The rabbit serum of anti-rat kidney was initially prepared, and then injected into normal rats to induce the formation of masugi nephritis. In this model, KZ-36 was administrated (i.p.) at the dosage of 50 microg/kg/d for 2 weeks, while saline and hydrocortisone were respectively used as negative and positive controls. The pharmacodynamic parameters were collected. RESULTS: After KZ-36 administration for one week, the protein output in 24 h urine remarkably decreased, and was 5.0 +/- 4.1 mg for two weeks, which was much less than 17.2 +/- 14.5 mg, a counterpart in saline control (P<0.01). KZ-36 could also reduce the serum level of creatinine and improve the renal pathological injury. CONCLUSION: KZ-36 has obvious therapeutic effects on masugi nephritis in rats.