Non-aspirin non-steroidal anti-inflammatory drugs in colorectal cancer: a review of clinical studies |
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| Authors: | Farzana Y. Zaman Suzanne G. Orchard Andrew Haydon John R. Zalcberg |
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| Affiliation: | 1.Department of Medical Oncology, The Alfred Hospital, Alfred Health, Melbourne, VIC Australia ;2.School of Public Health and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC 3004 Australia ;3.Head of Cancer Research Program, School of Public Health and Preventive Medicine, Faculty of Medicine, Monash University, Melbourne, VIC Australia |
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| Abstract: | Colorectal cancer (CRC) chemoprevention is an area of interest. Non-steroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory agents which have been identified as cancer chemoprevention agents given that inflammation is thought to contribute to tumorigenesis. Most studies have demonstrated that the NSAID, aspirin, plays a beneficial role in the prevention of CRC and colonic adenomas. Non-aspirin NSAIDs (NA-NSAIDs) have also been studied in CRC chemoprevention. There is increasing literature around their role in pre-cancerous polyp prevention and in decreasing CRC incidence and CRC-related outcomes in certain high-risk subgroups. However, the use of NA-NSAIDs may be accompanied by increased risks of toxicity. Further studies are required to establish the associations between concurrent aspirin and NA-NSAID use, and CRC-related outcomes.Subject terms: Colorectal cancer, Cancer prevention |
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