Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses |
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| Authors: | L. A. Basharova L. A. Vetrilé V. A. Evseev E. A. Gromova N. V. Bobkova L. A. Plakzhinas L. E. Fast |
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| Affiliation: | (1) Laboratory of Pathophysiology of the Immune System, Scientific Research Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow;(2) Laboratory of Neuromediator Systems, Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino |
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| Abstract: | The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 74, No. 10, pp. 1367–1372, October, 1988. |
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| Keywords: | conjugate antigen immunization antibodies neuromediators serotonin dopamine brain behavior |
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