Implication of the Pro12Ala polymorphism of the <Emphasis Type="Italic">PPAR-gamma 2</Emphasis>gene in type 2 diabetes and obesity in the French population期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Implication of the Pro12Ala polymorphism of the <Emphasis Type="Italic">PPAR-gamma 2</Emphasis>gene in type 2 diabetes and obesity in the French population

Authors:	Maya?Ghoussaini David?Meyre Stéphane?Lobbens Guillaume?Charpentier Karine?Clément Marie-Aline?Charles Ma?té?Tauber Jacques?Weill Email author" target="_blank">Philippe?Froguel Email author

Institution:	1.CNRS UMR 8090, Institute of Biology of Lille, Pasteur Institute,Lille,France;2.Endocrinology-Diabetology Unit, Corbeil-Essonnes Hospital,France;3.EA3502, H?tel-Dieu Hospital,Paris,France;4.INSERM U258, Paul Brousse Hospital,Villejuif,France;5.INSERM U563, Children's Hospital,Toulouse,France;6.Pediatric Endocrine Unit, Jeanne de Flandre Hospital,Lille,France;7.Genomic Medicine and Genome Centre, Hammersmith Campus,Imperial College London,UK

Abstract:	Background The Pro12Ala Single Nucleotide Polymorphism (SNP) of the Peroxisome Proliferator-Activated Receptor gamma 2 (PPAR-gamma 2) has been associated with insulin resistance and type 2 diabetes (T2D) and also inconsistently with obesity. The aim of this study was to evaluate the impact of this SNP with regards to T2D and childhood and adult obesity in the French Caucasian population.

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