醋酸奥曲肽注射液治疗急性重症胰腺炎的临床观察

目的对醋酸奥曲肽注射液治疗急性重症胰腺炎的临床疗效进行探讨分析。方法对本院接受诊治的80例急性重症胰腺炎患者的临床资料进行回顾性分析,对照组40例,行常规治疗;治疗组40例,在常规治疗的基础上行醋酸奥曲肽注射治疗。观察两组患者治疗前后血清淀粉酶的含量变化,并统计并发症的发生率。结果对照组25例血清淀粉酶恢复正常,恢复率为62.5%;治疗组37例血清淀粉酶恢复正常,恢复率为92.5%。对照组治疗后出现急性呼吸窘迫综合征（ARDS）、胰性脑病等并发症14例,发生率为35%;治疗组治疗后出现并发症6例,发生率为15%。治疗组的恢复率明显高于对照组,并发症发生率显著低于对照组,差异均有统计学意义（P〈0.05）。结论采用醋酸奥曲肽注射液治疗急性重症胰腺炎,不仅可以有效地降低血清淀粉酶的含量,还可以减少并发症的发生,具有良好的临床疗效。

Clinical observation of octreotide acetate injection in the treatment of severe acute pancreatitis

Objective To analyze the clinical curative effect of octreotide acetate injection in the treatment of severe acute pancreatitis. Methods The clinical data 80 cases of acute severe pancreatitis patients in the hospital were analyzed retrospectively, and 40 cases in control group were given routine treatment, treatment group 40 cases were given combined conventional treatment and octreotide acetate injection treatment. Serum amylase levels of patients in two groups before and after the treatment, and the incidence of complications, statistics were observed. Results Serum amylase levels of 25 cases in control group returned to normal, recovery rate was 62.5%; 37 cases in the treatment group recovered to normal serum amylase, recovery rate was 92.5%. After treatment, patients occurred cute respiratory distress syndrome （ARDS）, pancreatic encephalopathy and other complications in the control group, pancreatic encephalopathy and other complications occurred in 14 cases, the incidence was 35%; after treatment in treatment group 6 cases had complications, incidence rate was 15%. The total effective rate in treatment group was obviously higher than that in control group, the complication rate was significantly lower than the control group, the difference had statistical significance （P 0.05）. Conclusion Using octreotide acetate injection in the treatment of severe acute pancreatitis, can reduce serum amylase content effectively, and can reduce the incidence of complications, it has good clinical curative effect.