血浆硫化氢浓度与子宫肌瘤的相关性分析

目的分析子宫肌瘤血浆硫化氢（H2S）浓度的变化与子宫肌瘤的个数、最大直径以及子宫肌瘤相关危险因素的相关性。方法选择在本院进行子宫附件检查的妇女400例，进行B超探查，采用分光光度法测量血浆H：S浓度；比较子宫肌瘤患者与健康非子宫肌瘤人群血浆H2S浓度的差异；并分析血浆H2S浓度与年龄、家族子宫肌瘤史、口服避孕药和多次人工流产等子宫肌瘤相关危险因素的相关性。结果与健康非子宫肌瘤人群比较，子宫肌瘤患者血浆中H2S水平显著降低（P〈0．05）；子宫肌瘤患者血浆中H2S浓度与肌瘤的个数、肌瘤的最大直径以及与子宫肌瘤相关危险因素，如：年龄、家族子宫肌瘤史、口服避孕药和多次人工流产等均呈负相关（均P〈0．05）。结论子宫肌瘤患者的血浆H2S浓度低下，血浆H2S浓度的降低与子宫肌瘤的发生发展呈负相关。

Correlation Study Between Uterine Leiomyoma and Plasma Concentration of Hydrogen Sulfide

Objective To explore the correlation between uterine leiomyoma and plasma concentration of hydrogen sulfide （ H2 S）. Methods 400 women whose the adnexauteri were ekecked by type B ultrasound in our hospital were selected into our study. The concentration of plasmic H2S was tested by the spectrophotography. The difference between the patients with uterine leiomyoma and the healthy group without uterine leiomyoma was compared. The correlation between the concentration of plasmic H2 S and the related risk factors of uterine leiomyomas including the age, family history of uterine leiomyoma,cervical erosion,oral contraceptive medication and repeated abortion et al was analyzed by Pearson test. Re- suits Compared with the healthy group without uterine leiomyoma,the concentration of plasmic H2 S in the patients with uterine leiomyoma was significantly decreased （ P 〈0. 05 ）. The concentration of plasmic H2S in the patients with uterine leiomyoma was negatively correlated with the quantity of uterine leiomyomas, the maximum diameter of uterine leiomyoma, and the related risk factors of uterine leiomyomas including the age, family history of uterine leiomyoma, cervical erosion, oral contraceptive medication and repeated abortion （ all P 〈 0. 05 ）. Conclusion The concentration of plasmic H2 S in the patients with uterine leiomyoma was decreased and the decrease of the concentration of plasmic H2 S in the patients with uterine leiomyoma is negatively correlated with the occurrence and development of uterine leiomyoma.