Mixed carcinoma in situ: an immunohistochemical study |
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| Authors: | O. C. Peralta R. J. Barr S. G. Romansky |
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| Affiliation: | Section of Dermal Pathology and Histochemistry, Department of Dermatology, and Division of Surgical Pathology, University of California at Irvine, California, U.S.A.;Department of Pathology, University of California at Irvine, California, U.S.A. |
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| Abstract: | A case of mixed carcinoma in situ , of the skin, is presented. The lesion, located on the right temple of a 71–year-old man, showed histologic features of Bowen's disease and cxtramammary Paget's disease. This case suggests that Bowen's disease and extramammary Paget's disease may arise from pluripotential adnexal epithelium capable of keratinocytic and glandular differentiation. Utilization of the peroxidase-antiperoxidase technique for demonstrating carcino-embryonic antigen was performed in order to identify the component interpreted as extramammary Paget's disease. This procedure is apparently more sensitive than the commonly employed histochcmical stains for demonstrating glandular differentiation. |
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