| 蛋白激酶C抑制剂对脑缺血大鼠突触体游离钙的影响 |
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| 引用本文： | 陈康宁,董为伟. 蛋白激酶C抑制剂对脑缺血大鼠突触体游离钙的影响[J]. 第三军医大学学报, 2000, 22(1): 12-14 |
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| 作者姓名： | 陈康宁 董为伟 |
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| 作者单位： | 1. 第三军医大学附属西南医院神经内科,重庆,400038
2. 重庆医科大学神经病学研究所,重庆,400041 |
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| 基金项目： | 国家自然科学基金，39670269， |
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| 摘 要： | 目的：探讨蛋白激酶Ｃ（Ｐｒｏｔｅｉｎ ｋｉｎａｓｅ Ｃ，ＰＫＣ）参与神经损伤机制。方法：采用大鼠全脑缺血模型，观察脑缺血／再灌流后突触体游离钙的变化及ＰＫＣ的抑制剂灯盏花对突触体游离钙的影响。结果：脑缺血／再灌流可以导致突触体游钙增加的抑制剂灯盏花可以阻止脑缺血／再灌流导致突触体游离钙增加。结论：ＰＫＣ参与神经元缺血性损伤可能与其促进钙内流有关。
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| 关 键 词： | 钙超载 蛋白激酶C 抑制剂脑缺血 大鼠 突触 |
Effects of protein kinase C inhibitor on intraneuronal free calcium content in rats with cerebral ischemia |
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| CHEN Kang-ning,DONG Wei-wei. Effects of protein kinase C inhibitor on intraneuronal free calcium content in rats with cerebral ischemia[J]. Acta Academiae Medicinae Militaris Tertiae, 2000, 22(1): 12-14 |
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| Authors: | CHEN Kang-ning DONG Wei-wei |
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| Abstract: | Objective: To investigate the role of protein kinase C (PKC) in ischemic neuronal injury. Methods: After the model of ischemia/reperfusion was established in male Wistar rats, the changes of activity of PKC and intraneuronal free calcium content were observed. Meanwhile, the effects of Dengzhanhua, the PKC inhibitor, on the two parameters were also observed. Results: Cerebral ischemia/reperfusion resulted in the increase of intraneuronal free calcium content and activation of PKC. Dengzhanhua could prevent this change. Conclusion: PKC plays an important role in ischemic neuronal injury through inducing calcium overload. |
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| Keywords: | calcium overload protein kinase C cerebral ischemia/reperfusion |
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