The Association of HLA-B8 with Atrophic Thyroiditis |
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| Authors: | Hilda Moens John M Barnard John Bear Nadir R Farid |
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| Institution: | Thyroid Research Laboratory, Health Sciences Center, Memorial University of Newfoundland, St. John's, Newfoundland, Canada |
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| Abstract: | One-hundred-and-forty-seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA--B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57% vs. 26% for controls) but was identical to controls in 88 patients with goitrous thyroiditis (26%). No relation was found in either group between B8 and thyroid autoantibody titer or, in the case of goitrous thyroiditis, the rate of progression of the disease. Thus a link seems to be established between Graves' disease and atrophic thyroiditis in that both are significantly associated with HLA-B8. This study stresses the need to take clinical features into consideration when examining for HLA/disease associations. |
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