| 维药爱维心口服液对心肌缺血再灌大鼠髓过氧化物酶和丙二醛的影响 |
| |
| 引用本文： | 袁一木,王鹿,王蕊. 维药爱维心口服液对心肌缺血再灌大鼠髓过氧化物酶和丙二醛的影响[J]. 新疆医科大学学报, 2010, 33(1): 33-35 |
| |
| 作者姓名： | 袁一木 王鹿 王蕊 |
| |
| 作者单位： | 新疆医科大学基础医学院生理教研室,新疆,乌鲁木齐,830011 |
| |
| 摘 要： | 目的 探讨维药爱维心口服液对心肌缺血再灌大鼠髓过氧化物酶(MPO)和丙二醛(MDA)的影响.方法 40只雄性Wistar大鼠,随机分为4组:假手术组、缺血再灌(I/R)组、爱维心预处理组及爱维心缺血期给药组,每组10只.建立大鼠心肌缺血再灌注损伤(MIRI)模型.采用BL-420生物信号采集系统全程记录心电图;检测血浆和心肌MPO、MDA的变化.结果 (1)与I/R组比较.爱维心预处理组与爱维心缺血期给药组血浆MDA的含量、MPO活性均降低,差异有统计学意义(P<0.05～0.01);与I/R组比较,爱维心预处理组与爱维心缺血期给药组心肌MDA的含量和MPO活性均降低,差异有统计学意义(P<0.01).(2)爱维心缺血期给药组与爱维心预处理组比较,血浆和心肌MDA、MPO差异无统计学意义(P>0.05).结论 维药爱维心口服液能降低MIRI大鼠的MPO和MDA,对大鼠MIRI的保护作用可能与抑制白细胞的聚集和抗膜脂质过氧化有关.
|
| 关 键 词： | 爱维心口服液 心肌缺血再灌注损伤 丙二醛 髓过氧化物酶 |
Influence of Aiweixin oral liquor on MPO and MDA in MIRI rat |
| |
| YUAN Yi-mu,WANG Lu,WANG Rui. Influence of Aiweixin oral liquor on MPO and MDA in MIRI rat[J]. Journal of Xinjiang Medical University, 2010, 33(1): 33-35 |
| |
| Authors: | YUAN Yi-mu WANG Lu WANG Rui |
| |
| Affiliation: | YUAN Yi-mu,WANG Lu,WANG Rui(Department of Physiology,Preclinical Medical College,Xinjiang Medical University,Urumqi 830011,China) |
| |
| Abstract: | Objective To investigate the influence of Aiweixin oral liquor on MPO and MDA in MIRI rat. Methods Forty Wistar male rats were divided into four groups randomly:sham operation group,ischemia reperfusion injury group (I/R),Aiweixin precondition group and Aiweixin ischemic group. There were 10 rats in each group. The model of MIRI was produced,all the ECG were collected by the BL-420 biological signal collected system,and the variation of MPO and MDA in plasma and heart muscle were detected respectively. Resu... |
| |
| Keywords: | Aiweixin oral liquor myocardial reperfusion injury maleic dialdehyd myeloperoxidace |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
