Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation |
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Authors: | de Groot Sonja Dallmeijer Annet J Post Marcel W Angenot Edmond L van den Berg-Emons Rita J van der Woude Luc H |
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Institution: | a Rehabilitation Center Amsterdam, Amsterdam, The Netherlands b Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Amsterdam, The Netherlands c Department of Rehabilitation Medicine, VU University Medical Center; Amsterdam, The Netherlands d Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands e Department of Rehabilitation Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. |
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Abstract: | de Groot S, Dallmeijer AJ, Post MW, Angenot EL, van den Berg-Emons RJ, van der Woude LH. Prospective analysis of lipid profiles in persons with a spinal cord injury during and 1 year after inpatient rehabilitation.ObjectivesTo investigate the course of lipid profiles during and 1 year after inpatient rehabilitation of persons with spinal cord injury, and to determine which personal, lesion, and lifestyle characteristics influence the changes in lipid profiles over time and among subjects.DesignMultilevel regression analysis of measurement points during and after rehabilitation.SettingEight rehabilitation centers in The Netherlands.ParticipantsPeople with complete and incomplete paraplegia and tetraplegia (N=180).InterventionsNot applicable.Main Outcome MeasuresTotal cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG), and the TC/HDL ratio.ResultsWe found a significant decrease in TG and TC/HDL during inpatient rehabilitation and a significant increase in HDL during and after inpatient rehabilitation. TC and LDL, however, showed unfavorable increases after clinical discharge. The changes in HDL and LDL over time differed between lesion groups. An increase in the body mass index (BMI) led to an unfavorable change in all lipid profiles. Older participants showed higher TC, LDL, and HDL concentrations. Women and participants who consumed some alcohol, or who were more active 1 year after discharge, had more favorable HDL levels.ConclusionsLipid profiles improved during inpatient rehabilitation but deteriorated somewhat after clinical discharge. Controlling one’s BMI seems important in diminishing the risk for unfavorable lipid profiles. |
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Keywords: | Cardiovascular diseases Life style Lipids Rehabilitation Spinal cord injuries |
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