Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury |
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Authors: | Liang Huifang Mojtahedi Mina C Chen David Braunschweig Carol L |
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Institution: | a Department of Human Nutrition, University of Illinois, Chicago, IL b Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, IL c Spinal Cord Injury Acute Care and Rehabilitation, Northwestern Memorial Hospital and Rehabilitation Institute of Chicago, Chicago, IL. |
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Abstract: | Liang H, Mojtahedi MC, Chen D, Braunschweig CL. Elevated C-reactive protein associated with decreased high-density lipoprotein cholesterol in men with spinal cord injury.ObjectivesTo determine if people with spinal cord injury (SCI) have elevated C-reactive protein (CRP), to examine the association of CRP with high-density lipoprotein cholesterol (HDL-C), and to assess the influence of completeness and level of injury on these parameters.DesignCross-sectional.SettingUrban university.ParticipantsMen with SCI (n=129) who were free of infection and/or recent anti-inflammatory medication use as well as their 1:1 age- and race-matched able-bodied counterparts from the 1999-2002 National Health and Nutrition Examination Surveys.InterventionsNot applicable.Main Outcome MeasuresHigh CRP was defined as 3mg/L or higher and low HDL-C as less than 1.04mmol/L.ResultsMen with SCI were more likely to have high CRP (odds ratio OR]=2.29; 95% confidence interval CI], 1.33-3.95) and low HDL-C (OR=1.81; 95% CI, 1.01-3.27). The OR for low HDL-C in SCI was no longer significant when high CRP was controlled. CRP was higher in complete versus incomplete injury (median, 3.7mg/L vs 1.2mg/L; P=.005), and this elevation was independent of age, smoking, physical activity, waist circumference, and weight. No conclusion can be made on the association of injury level and CRP because of a lack of power.ConclusionsThe elevated CRP, possibly the major risk factor, together with decreased HDL-C may contribute to greater incidence for cardiovascular disease in the SCI population. |
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Keywords: | C-reactive protein Cholesterol HDL Cross-sectional studies Rehabilitation Risk factors Spinal cord injuries |
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