急性胰腺炎患者凝血功能、血小板相关参数的改变及其临床意义

目的探讨急性胰腺炎（AP）患者凝血功能、血小板相关参数的改变及其临床意义。方法将36例AP患者作为AP组,38例健康者作为对照组,检测对照组健康者及AP组患者入院时、缓解期血清淀粉酶、脂肪酶、白细胞、中性粒细胞、淋巴细胞、血小板、平均血小板体积（MPV）、血小板分布宽度（PDW）、凝血酶原时间（PT）、凝血酶时间（TT）、活化部分凝血活酶时间（APTT）、凝血酶原活动度（PTA）、国际标准化比值（INR）、纤维蛋白原（FIB）及D-二聚体（D-D）水平。结果 AP组患者血清淀粉酶、脂肪酶、TT、INR、FIB、D-D水平明显高于对照组（P〈0.01）,而其PT、PTA水平明显低于对照组（P〈0.01）。AP患者入院时白细胞、中性粒细胞、淋巴细胞及MPV与缓解期的差异有统计学意义（P〈0.01）。结论对AP患者凝血功能、血小板相关参数改变的检测有助于患者病情及预后的评估。

Changes of coagulation function and platelet-related parameters of patients with acute pancreatitis and their clinical significance

Objective To study the changes of coagulation function and platelet-related parameters of patients with acute pancre-atitis（AP） and their clinical significance .Methods 36 patients with AP were served as the AP group ,38 healthy people ,the control group .Healthy people in the control group and patients in the AP group at the time of admission and remission were subjected to detection of serum amylase ,lipase ,leukocytes ,neutrophils ,lymphocytes ,platelets ,mean platelet volume（MPV） ,platelet distribution width（PDW）,prothrombin time（PT）,thrombin time（TT）,activated partial thromboplastin time（APTT）,prothrombin activity （PTA） ,international normalized ratio （INR） ,fibrinogen（FIB） and D-dimer（D-D） levels .Results Levels of serum amylase ,lipase , TT ,INR ,FIB ,and D-D of patients in AP group were significantly higher than those in the control group（P〈0 .01） ,while their PT , PTA levels were significantly lower than those in the control group （P〈0 .01） .Differences of leukocytes ,neutrophils ,lymphocytes and MPV of AP patients between at the time of admission and remission were statistically significant （P〈0 .01） .Conclusion De-tections of coagulation function and platelet-related parameters changes of AP patients contribute to evaluation of the patients′con-dition and prognosis .