脑梗死患者同型半胱氨酸、凝血功能、血小板参数和血液流变学指标检测的临床意义

目的探讨脑梗死患者同型半胱氨酸（Hcy）、凝血功能、血小板参数和血液流变学指标检测的临床价值。方法将114例脑梗死患者作为脑梗死组,112例健康者作为对照组。检测其血小板参数、凝血功能、Hcy及血液流变学参数。结果脑梗死组患者Hcy、纤维蛋白原（Fib）、D-二聚体（D-D）均高于对照组（P〈0.05）,两组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）的差异无统计学意义（P〉0.05）;脑梗死组患者血小板计数（PLT）低于对照组,血小板分布宽度（PDW）和平均血小板体积（MPV）高于对照组,差异有统计学意义（P〈0.05）,两组血小板压积（PCT）的差异无统计学意义（P〉0.05）;脑梗死组患者全血黏度、血浆黏度、红细胞比容均高于对照组（P〈0.05）。结论 Hcy、凝血功能、血小板参数和血液流变学指标的检测对脑梗死的病情预测和早期诊治有重要意义。

Clinical Significance of homocysteine,coagulation function,platelet parameters and hemorheology detection in patients with cerebral infarction

Objective To investigate the clinical value of homocysteine（Hcy） ,coagulation function ,platelet parameters and he-morheology detection in patients with cerebral infarction .Methods 114 patients with cerebral infarction were served as cerebral in-farction group ,while 112 healthy people as control group .Their platelet parameters ,coagulation function ,Hcy and hemorheology were detected .Results Hcy ,Fibrinogen（Fib） and D-dimer（D-D） of patients in cerebral infarction group were higher than those in control group（P〈0 .05） ,while the differences of prothrombin time（PT） ,activated partial thromboplastin time（APTT） and throm-bin time（TT） between the two groups showed no statistically significant （P〉 0 .05） .In cerebral infarction group ,platelet count （PLT） of patients was lower ,and platelet distribution width（PDW） and mean platelet volume（MPV） were higher than those in the control group（P〈0 .05） while plateletcrit（PCT） showed no statistically significant difference between the two groups （P〈0 .05） . Whole blood viscosity ,plasma viscosity and hematocrit of patients in the cerebral infarction group were higher than those in the con-trol group（P〈 0 .05） .Conclusion Hcy ,coagulation function ,platelet parameters and hemorheology detection have important significance for prediction and early diagnosis and treatment of cerebral infarction .