帕米膦酸二钠联合153Sm-EDTMP对恶性肿瘤多发骨转移的疗效分析

目的 探讨帕米膦酸二钠（博宁）联合＾１５３Ｓｍ－ＥＤＴＭＰ对恶性肿瘤多发骨转移的临床疗效。方法 ３２例恶性肿瘤多发骨转移患者随机分为２组，每组１６例，分别接受＾１５３Ｓｍ－ＥＤＴＭＰ单独或与帕米膦酸二钠联合治疗。结果 联合组疼痛总缓解率（ＣＲ＋ＰＲ）为９３．８％，单用组为６２．５％，骨病灶控制总有效率（ＣＲ＋ＰＲ）联合组５６．３％，单用组为１８．８％，联合组疗效优于单用组（Ｐ〈０．０５），两组均无

ANALYSIS OF THERAPEUTIC EFFECT OF PAMIDRONATE COMBINED WITH~(153) Sm-EDTMP IN PATIENTS WITH CANCER AND MULTI BONE METASTASES

Objective To evaluate therapeutic effect of Pamidronate combined with 153 Sm EDTMP in patients with cancer and mulit bone metastases.Methods 32 patients with cancer and multi bone metastases were divided randomly into two groups,16 patients receive only 153 Sm EDTMP,16 patients with addition of Pamidronate.Results Respones rate of bone pain relief was 93 8 % in Pamidronate combined with 153 Sm EDTMP group and 62 5 % in 153 Sm EDTMP alone group.Response rate of bone metastases was 56 3 % in Pamidronate combined with 153 Sm EDTMP group and 18 8 % in 153 Sm EDTMP alone group.The therapeutic effect of Pamidronate combined with 153 Sm EDTMP group is better than that of 153 Sm EDTMP alone group ( P <0 05).No serious side effects were found in both group.Conclusion Pamidronate combined with 153 Sm EDTMP is the best way to treat the patients with cancer and multi bone metastases at present.