度洛西汀与帕罗西汀治疗抑郁症的对照研究

目的探讨度洛西汀治疗抑郁症的疗效和安全性。方法 72例抑郁症患者随机分为观察组和对照组各36例,观察组应用度罗西汀治疗,对照组应用帕罗西汀治疗,疗程6周,于治疗前和治疗第1、2、4、6周末采用汉密尔顿抑郁量表（HAMD）和临床疗效总评量表（CGI-SI）评价疗效,以治疗中需处理的不良反应症状量表（TESS）评价安全性。结果治疗后2组各时间点HAMD评分均低于治疗前,差异有统计学意义（P〈0.05和P〈0.01）。治疗后同期2组间HAMD总分比较差异无统计学意义（P〉0.05）。2组临床疗效比较差异无统计学意义（P〉0.05）。2组治疗6周末CGI-SI评分均低于治疗前,差异有统计学意义（P〈0.01）,但2组间比较差异无统计学意义（P〉0.05）。2组不良反应发生率比较差异无统计学意义（P〉0.05）。结论度洛西汀治疗抑郁症与帕罗西汀疗效相当,安全有效。

Comparative study of duloxetine and paroxetine in the treatment of depression

Objective To determine the efficacy and safety of duloxetine in the treatment of depression.Methods 72 patients with depression were randomly assigned to study group（duloxetine） and control group（paroxetine） for 6 weeks.The clinical efficacy was evaluated using HAMD as well as CGI-SI,and the side effects were evaluated by TESS after 1、2、4、6 weeks treatment.Results After treatment,HAMD score in both groups were lower than those before treatment at each time point,and the differences were statistically significant（P0.05 and P0.01）.There were no significant difference in HAMD score and clinical effect between the two groups（P0.05）,6 weeks after treatment,CGI-SI scores in both groups were lower than those before treatment,and the differences were significant（P0.01）,but the difference between the two groups was not statistically significant（P 0.05）.The incidence of adverse reactions showed no significant difference between the two groups（P0.05）.Conclusion Duloxetine and paroxetine are both effective and safe in patients with depressive disorder.