| 慢性丙型肝炎患者HCV基因型分析 |
| |
| 引用本文： | 潘剑,俞海英,丁巧云,王雷,曹兴国. 慢性丙型肝炎患者HCV基因型分析[J]. 实用肝脏病杂志, 2012, 15(5): 390-391 |
| |
| 作者姓名： | 潘剑 俞海英 丁巧云 王雷 曹兴国 |
| |
| 作者单位： | 210003,南京市 东南大学附属第二医院肝病科15病区 |
| |
| 摘 要： | 目的研究慢性丙型肝炎患者HCV基因型概况。方法采用基因芯片法检测HCV基因分型;采用PCR法测定HCV RNA定量。结果在570例患者中,HCV RNA阳性552例（95%）,其中1b型400例（72.4%）,2a型63例（11.4%）,3a型20例（3.6%）,3b型20例（3.6%）,1b＋2a型12例（2.1%）,1a型2例（0.4%）,6型7例（1.26%）,1b＋3a型1例（0.18%）,2a＋1b型3例（0.5%）,未定型24例（4.3%）;不同HCV基因型感染者血清HCVRNA水平无统计学差异（P〉0.05）。结论本组患者HCV基因型以1b型为主,2a型次之,多种混合型的出现提示HCV基因型呈现多样化趋势。
|
| 关 键 词： | 慢性丙型肝炎 丙型肝炎病毒基因型 HCV RNA |
Genotypes of hepatitis C virus in patients with chronic hepatitis C |
| |
| Affiliation: | Pan Jian,Yu Haiying,Ding Qiaoyun,et al.Department of Liver Diseases,Second Hospital Affiliated to East-West University,Nanjing 210003 |
| |
| Abstract: | Objectives To investigate the genotypes of hepatitis C virus in patients with chronic hepatitis C.Method The genotypes of hepatitis C virus was detected by gene chips and serum hepatitis C viral RNA was assayed by RT-PCR.Results Out of 570 sera,552(95%) were positive for HCV RNA,and 1b were positive in 400(72.4%),2a in 63(11.4%),3a in 20(3.6%),3b in 20(3.6%),1b+2a in 12(2.1%),1a in 2(0.4%),6 in 7(1.26%),1b+3a in one(0.18%),2a+1b in 3(0.5%),and unknown in 24(4.3%);Serum HCV RNA levels in patients with different hepatitis C viral genotype infection were not significantly different(P>0.05).Conclusion The hepatitis C virus of genotype 1b dominated,and 2a in the second place in our series;Some mix infection with multiple genotypes needs further investigation. |
| |
| Keywords: | Hepatitis C Genotypes of hepatitis C virus HCV RNA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
