| C-反应蛋白在大鼠自体静脉移植动脉化中的作用 |
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| 引用本文： | 周经月,葛建军,赵智伟,邬松,Abendroth D K.C-反应蛋白在大鼠自体静脉移植动脉化中的作用[J].安徽医科大学学报,2011,46(12):1257-1259. |
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| 作者姓名： | 周经月 葛建军 赵智伟 邬松 Abendroth D K |
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| 作者单位： | 安徽医科大学第一附属医院心脏外科,合肥,230022;德国乌尔姆大学心脏移植研究中心,乌尔姆,89069 |
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| 基金项目： | 安徽省科技厅重点项目(编号:07020303071) |
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| 摘 要： | 目的 探讨C-反应蛋白(CRP)在自体静脉移植动脉化中是否参与血管重塑过程.方法 通过建立自体静脉移植动脉化模型,CBS3830加以干预,应用ELISA法检测CRP水平;术后1周和2周检测内膜厚度;Western blot法检测p38、P-p38表达.结果 0～2周各时间点内,模型组CRP水平呈逐渐上升趋势,假手术组呈...
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| 关 键 词： | p38MAPK抑制剂 静脉动脉化 内膜增生 CRP p38 静脉桥 |
Effect of C-reactive protein on autologous vein graft arterial of rat |
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| Zhou Jingyue,Ge Jianjun,Zhao Zhiwei,et al.Effect of C-reactive protein on autologous vein graft arterial of rat[J].Acta Universitis Medicinalis Anhui,2011,46(12):1257-1259. |
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| Authors: | Zhou Jingyue Ge Jianjun Zhao Zhiwei |
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| Institution: | Zhou Jingyue,Ge Jianjun,Zhao Zhiwei,et al(Dept of Cardiovascular Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To discuss if C-reactive protein(CRP) involved in vascular remodeling in the process of venous vein graft arterialization.Methods Interfection with CBS3830,enzyme-linked immunosorbent assay(ELSIA) was used to detect the serum levels of CRP.Detected the intima thickness at 1,2 week in each group.Western blot was used to detect the expression of p38,p-p38.Results At 0~2 weeks each time point,CRP levels in the model group showed a gradual upward trend,while that in the sham group increased at first,a... |
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| Keywords: | p38MAPK inhibitor vein arterialization vein grafts CRP p38 vein-bridge |
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