藏药独一味总环烯醚萜对纤溶系统的实验研究 |
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引用本文: | 张泉龙,李茂星,张文娟,邱建国,何希瑞,贾正平. 藏药独一味总环烯醚萜对纤溶系统的实验研究[J]. 安徽医药, 2011, 15(12): 1475-1477 |
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作者姓名: | 张泉龙 李茂星 张文娟 邱建国 何希瑞 贾正平 |
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作者单位: | 兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050;兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050;兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050;兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050;兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050;兰州军区兰州总医院药剂科,全军高原环境损伤防治重点实验室,甘肃,兰州,730050 |
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基金项目: | 国家科技部重大新药创制军队特需药保密专项 |
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摘 要: | 目的探讨独一味总环烯醚萜苷对大鼠机体纤溶系统的影响。方法通过对大鼠优球蛋白溶解时间、全血浆凝块溶解时间以及血浆复钙溶解时间的测定,评价独一味总环烯醚萜苷对纤溶功能和凝血功能的影响。结果独一味总环烯醚萜苷能明显延长大鼠优球蛋白溶解时间和全血浆凝块溶解时间,延长离体大鼠血浆复钙时间。结论独一味总环烯醚萜苷能通过抑制纤溶激活物而发挥止血作用。
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关 键 词: | 独一味 总环烯醚萜苷 优球蛋白溶解法 纤溶激活物 |
Effect of iridoid glycosides extract from lamiophlomis rotata on blood fibrinogenlysis system |
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Affiliation: | ZHANG Quan-long,LI Mao-xing,ZHANG Wen-juan,et al(Department of Pharmacy,Lanzhou General Hospital of PLA,Key Laboratory of the Prevention and Cure for the Plateau Environment Damage,PLA,Lanzhou,Gansu 730050,China) |
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Abstract: | Aim To study the hemostatic effects of iridoid glycosides extract from Lamiophlomis Rotata(IGLR).Methods The changing of the euglobulin lysis time(ELT) and the whole plasma clot lysis time were evaluated after oral administration of IGLR for 7 days.The plasma recalcification times(RT) of rats were tested in vitro.Results IGLR can prolong the ELT,the whole plasma clot lysis time and RT obviously.Conclusion IGIR might play the hemostatic effect as one of plasminogen inhibitor. |
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Keywords: | Lamiophlomis Rotata iridoid glycosides euglobulin lysis plasminogen activator |
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