畅心饮改善冠心病心肌缺血及其机制初步研究

目的观察畅心饮对冠心病心绞痛与中医证候疗效、心肌缺血的改善作用,并探究其可能机制。方法将66例冠心病患者分为2组,对照组（32例）按常规西医治疗,治疗组（34例）在常规西医治疗基础上加服畅心饮,观察畅心饮对心绞痛与中医证候的疗效及对缺血总负荷（total ischemic burden,TIB）、体质量指数（body mass index,BMI）、超敏C反应蛋白（high sensitive C-reactive protein,hs-CRP）以及低密度脂蛋白胆固醇（low density lipoprotein-cholesterol,LDL-C）和总胆固醇（total cholesterol,TC）的影响。结果与对照组相比,畅心饮可进一步改善心绞痛和降低中医证候积分,进一步降低TIB、LDL-C、TC与hs-CRP水平。结论畅心饮可改善冠心病心肌缺血,其机制可能与调控血脂水平、舒缓冠状动脉内炎性反应有关。

Changxinyin Decoction for Ameliorating Cardiac Ischemia of Coronary Heart Disease and Its Underlying Mechanisms: A Pilot Clinical Study

Objective To observe the effects of Changxinyin Decoction（a traditional Chinese medicine mainly composed of coptis,pinellia,snakegourd fruit,salvia miltiorrhiza,earthworm,cassia twig,and astragalus） on angina pectoris,traditional Chinese medicine（TCM） syndromes and cardiac ischemia in coronary heart disease patients,and explore its underlying mechanisms.Methods A total of 66 patients with coronary heart disease were divided into 2 groups.Thirty-two patients in the control group were treated with conventional western therapies;additionally,34 patients in the treatment group were treated with Changxinyin Decoction.The therapeutic effects of Changxinyin Decoction on angina pectoris and TCM syndromes were observed;and its effects on total ischemic burden（TIB） and body mass index（BMI） as well as the levels of high sensitive C-reactive protein（hs-CRP） and blood lipids,including low density lipoprotein-cholesterol（LDL-C） and total cholesterol（TC）,were observed also.Results As compared to conventional western therapies,Changxinyin Decoction could further alleviate angina pectoris,reduce scores of TCM syndromes,and further lower the levels of TIB,hs-CRP,LDL-C,and TC.Conclusion Changxinyin Decoction can alleviate cardiac ischemia;the underlying mechanisms might be related with lowering blood lipids,and inhibiting the inflammation in the coronary artery.