| 肿瘤标志物EpCAM在胃癌组织中的表达 |
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| 引用本文： | 鲁明典,刘弋,徐振山. 肿瘤标志物EpCAM在胃癌组织中的表达[J]. 安徽医学, 2011, 32(11): 1801-1804. DOI: 10.3969/j.issn.1000-0399.2011.11.001 |
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| 作者姓名： | 鲁明典 刘弋 徐振山 |
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| 作者单位： | 230022合肥,安徽医科大学第一附属医院普外科二病区 |
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| 基金项目： | 安徽省临床医学重点学科应用技术计划项目(项目编号:05A036) |
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| 摘 要： | 目的 利用组织芯片技术研究91例胃癌中EpCAM的表达及临床意义.方法 选取91例胃癌癌灶组织为实验组,随机选取79例取其癌灶远隔组织胃黏膜为对照组.采用组织芯片及免疫组化技术分析组织中EpCAM表达情况,分析胃癌组EpCAM表达与C12结果的差异性.结果 91例胃癌组织中EpCAM阳性率为92.3％;对照组组织EpC...
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| 关 键 词： | 胃癌 肿瘤标志物 EpCAM 免疫组织化学技术 组织芯片 |
The expression of tumor marker - EpCAM in the tissue of gastric cancer and its clinical value |
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| Lu Mingdian,Liu Yi,Xu Zhenshan. The expression of tumor marker - EpCAM in the tissue of gastric cancer and its clinical value[J]. Anhui Medical Journal, 2011, 32(11): 1801-1804. DOI: 10.3969/j.issn.1000-0399.2011.11.001 |
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| Authors: | Lu Mingdian Liu Yi Xu Zhenshan |
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| Affiliation: | shan Dpartment of General Surgery,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China |
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| Abstract: | Objective To study the expression of a new tumor marker EpCAM in gastric cancer and its clinical value.Methods The specimens were obtained from 91 pstients with primary gastric cancer and 79 normal controls.The EpCAM was detected by tissue microarray and Immunohistochemistry.The relationship of EpCAM protein expression in tumors tissue and normal tissue was analyzed.Results EpCAM was expressed in 84 cases of 91 gastric cancers,the positive expression rates was 92.3%.There were 11 cases with EpCAM positive expression(13.9%).in 79 normal controls The positive expression of EpCAM in gastric carcinoma was significantly higher than that in control.The over-expression of EpCAM in gastric cancer was not related to the sex,age,location,the depth of invasion,the histological,differention,Borrmann types,pTNM types,et al.Conclusion EpCAM posotive expression may be served as a marker in the diagnosis of gastric cancer,but not related with the disease condition |
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| Keywords: | Gastric cancer Tumor marker EpCAM Immunohistochemistry Tissue microarray |
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