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环磷腺苷葡胺对老年慢性心力衰竭患者心功能及B型利钠肽的影响
引用本文:余飞,张珺琳,李斌,张艳,汪丹丹. 环磷腺苷葡胺对老年慢性心力衰竭患者心功能及B型利钠肽的影响[J]. 安徽医药, 2011, 15(12): 1575-1576
作者姓名:余飞  张珺琳  李斌  张艳  汪丹丹
作者单位:安徽省铜陵市人民医院干部科、老年科,安徽,铜陵,244000;安徽省铜陵市人民医院干部科、老年科,安徽,铜陵,244000;安徽省铜陵市人民医院干部科、老年科,安徽,铜陵,244000;安徽省铜陵市人民医院干部科、老年科,安徽,铜陵,244000;安徽省铜陵市人民医院干部科、老年科,安徽,铜陵,244000
摘    要:目的探讨环磷腺苷葡胺治疗老年慢性心力衰竭(CHF)的疗效及对B型利钠肽(B-type natriuretic peptide,BNP)的影响。方法将54例老年CHF患者随机分为治疗组和对照组,治疗组在对照组基础上加用环磷腺苷葡胺,疗程12 d。给药前及治疗后12 d分别测定血浆BNP浓度,并观察NYHA心功能分级改善状况。结果治疗组心功能分级改善明显优于对照组(P<0.05),血浆BNP浓度比对照组显著降低(P<0.05)。结论环磷腺苷葡胺可改善老年CHF患者的心功能,降低血浆BNP浓度。

关 键 词:环磷腺苷葡胺  B型利钠肽  心力衰竭  心功能

Effect of meglumine adenosine cyclophosphate on the level of B-type natriuretic peptide and heart function in elderly patients with chronic heart failure
YU Fei,ZHANG Jun-lin,LI Bin,et al. Effect of meglumine adenosine cyclophosphate on the level of B-type natriuretic peptide and heart function in elderly patients with chronic heart failure[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(12): 1575-1576
Authors:YU Fei  ZHANG Jun-lin  LI Bin  et al
Affiliation:YU Fei,ZHANG Jun-lin,LI Bin,et al(The People Hospital of Tongling,Tongling,Anhui 244000)
Abstract:Aim To investigate the effect of meglumine adenosine cyclophosphate on the level of B-type natriuretic peptide and heart function in elderly patients with chronic heart failure.Methods 54 elderly patients with chronic heart failure were randomly divided into control group(accepted normal comprehensive treatment) and treatment group(medicine used in control group plus meglumine adenosine cyclophosphate for 12 days).Plasma BNP levels,NYAH(Nen York Heart Association class) were evaluated before and after 12 days' therapy.Results In treatment group,NYHA class improved obviously(P〈0.05),BNP level lower obviously than those in control group(P〈0.05).Conclusion Meglumine adenosine cyclophosphate may obviously improve patients'cardiac function and lower plasma BNP level for patients with CHF.
Keywords:meglumine adenosine cyclophosphate  B-type natriuretic peptide  heart failure  cardiac function
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