瑞舒伐他汀与阿托伐他汀治疗老年高胆固醇血症的疗效和安全性比较

目的比较瑞舒伐他汀10 mg·d~(-1)与阿托伐他汀20 mg·d~(-1)治疗老年高胆固醇血症病人的疗效和安全性。方法采用单盲随机对照的前瞻性研究。经4 wk调脂药物洗脱的老年病人67例,空腹血脂符合低密度脂蛋白-胆固醇(LDL-C)≥4.14 mmol·L~(-1)且≤6.50 mmol·L~(-1)、三酰甘油(TG)<4.52 mmol·L~(-1)入组标准,随机分为瑞舒伐他汀组(n=33,瑞舒伐他汀10 mg·d~(-1))和阿托伐他汀组(n=34,阿托伐他汀20 mg·d~(-1)),疗程4 wk,观察2药的疗效和安全性。结果治疗4 wk后,瑞舒伐他汀组病人血清LDL-C显著降低(3.4±s0.9)mmol·L~(-1) vs(2.8±0.8)mmol·L~(-1),P<0.05],总胆固醇(TC)亦显著降低(5.5±1.1)mmol·L~(-1)vs(4.8±0.9)mmol·L~(-1),P<0.051,HDL-C和TG无明显改变(P>0.05);阿托伐他汀组病人血清LDL-C水平也显著降低,(3.3±1.2)mmol·L~(-1) vs(2.4±0.7)mmol·L~(-1),P<0.05],TC降低明显(5.2±1.2)mmo]·L~(-1)vs(4.5±0.6)mmol·L~(-1),P<0.05],HDL-C和TG无显著改变(P>0.05)。2组间比较各指标均无显著差异(P>0.05)。研究期间未发现与药物有关的严重不良事件。结论瑞舒伐他汀和阿托伐他汀均为安全快速降低老年人群LDL-C的候选药物。

Efficacy and safety of rosuvastatin and atorvastatin in aged patients with hypercholesterolemia

AIM To compare the efficacy and safety of rosuvastatin and atorvastatin in aged patients with hypercholesterolemia.METHODS After a 4-week dietary run-in period,a single-blinding,randomized cont- roled trial was conducted in 67 aged patients with LDL-C levels≥4.14 and≤6.50 mmol·L~(-1) and triglyceride (TG)levels≤4.52 mmol·L~(-1),which were randomized into rosuvastatin group(R group)and atorvastatin group(A group).Thirty-three patients in R group was treated with rosuvastatin 10 mg·d~(-1) and thirty-four patients in A group were administered with atorvastatin 20 mg·d~(-1) for 4 weeks,respectively.The efficacy and safety were observed.RESULTS The LDL-C level(3.4±0.9) mmol·L~(-1) vs(2.8±0.8)mmol·L~(-1) in R group and(3.3±1.2)mmol·L~(-1)vs(2.4±0.7)mmol·L~(-1) in A group,P<0.05]and TC level(5.5±1.1) mmol·L~(-1) vs(4.8±0.9)mmol·L~(-1) in R group and(5.2±1.2) mmol·L~(-1)vs(4.5±0.6)mmol·L~(-1) in A group,P<0.05] decreased significantly after 4 weeks treatment.TG and HDL-C levels before and after the treatment were no difference in both groups(P>0.05).There was no significant difference between two groups(P>0.05) .None of drug related SAE was found during the study.CONCLUSION Both rosuvastatin and atorvastatin are worthy of recommendation to aged patients with hypercholesterolemia.