| 复方鳖甲片预防肺纤维化大鼠细胞外基质过度形成的实验研究 |
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| 引用本文： | 张东伟,王继峰,牛建昭,李健,杨美娟,金焕,高宝华. 复方鳖甲片预防肺纤维化大鼠细胞外基质过度形成的实验研究[J]. 中草药, 2004, 35(5): 545-548 |
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| 作者姓名： | 张东伟 王继峰 牛建昭 李健 杨美娟 金焕 高宝华 |
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| 作者单位： | 北京中医药大学,细胞与生化实验室,北京,100029 |
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| 基金项目： | 国家自然科学基金重点项目 ( 3 0 13 0 2 2 0 )，教育部首批非典科技攻关项目 ( 15 ) |
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| 摘 要： | 目的 研究复方鳖甲片预防盐酸博莱霉素致大鼠肺纤维化细胞外基质过度沉积的作用。方法 SD雄性大鼠气管滴注盐酸博莱霉素造模，第2天ig复方鳖甲片1．4，0．7，0．35g／kg，每周连续给药6d，给药4周，观察第28天时大鼠肺组织羟脯氨酸和血清中Ⅲ型胶原(Ⅲ-C)、Ⅳ型胶原(Ⅳ-C)及层黏连蛋白(LN)和透明质酸(HA)的含量，同时取肺组织行HE、Masson染色。结果 复方鳖甲片可降低肺纤维化大鼠血清Ⅲ-C、Ⅳ一C，LN及HA的含量，降低肺组织纤维性增生。结论 复方鳖甲片可能是通过降低肺纤维化大鼠细胞外基质含量而发挥治疗作用。
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| 关 键 词： | 复方鳖甲片 肺纤维化 Ⅲ型胶原 Ⅳ型胶原 层黏连蛋白 透明质酸 |
| 文章编号： | 0253-2670(2004)04-0545-04 |
| 收稿时间： | 2003-08-03 |
Experimental study on protection of Compound Biejia Tablet on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats |
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| Zhang Dong-wei,Wang Ji-feng,Niu Jian-zhao,Li Jian,Yang Mei-juan,Jin Huan and Gao Bao-hua. Experimental study on protection of Compound Biejia Tablet on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats[J]. Chinese Traditional and Herbal Drugs, 2004, 35(5): 545-548 |
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| Authors: | Zhang Dong-wei Wang Ji-feng Niu Jian-zhao Li Jian Yang Mei-juan Jin Huan Gao Bao-hua |
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| Affiliation: | Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China;Laboratory of Cell and Biochemistry, Beijing University of Traditional Chinese Medicine, Beijing 100029, China |
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