| 环丙沙星与甲磺酸左氧氟沙星抗生素后效应比较研究 |
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| 引用本文： | 邢丽,许岚.环丙沙星与甲磺酸左氧氟沙星抗生素后效应比较研究[J].天津医科大学学报,2007,13(1):93-95. |
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| 作者姓名： | 邢丽 许岚 |
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| 作者单位： | 1. 天津市中心妇产科医院药剂科,天津,300052
2. 天津市长征医院 |
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| 摘 要： | 目的:比较甲磺酸左氧氟沙星和环丙沙星的抗生素后效应(PAE)。方法:采用微生物分析仪的光密度法测定。结果:环丙沙星和甲磺酸左氧氟沙星对革兰阳性球菌和革兰阴性杆菌均能产生较明显的PAE,且随着浓度增大而逐渐延长,呈显著的浓度依赖性。甲磺酸左氧氟沙星对金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌的PAE明显长于环丙沙星。结论:在设计左氧氟沙星的临床给药方案时,可适当延长给药间隔,可以采取1次/天给药方案,仍能维持良好的抗菌效果。
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| 关 键 词： | 抗生素后效应 环丙沙星 甲磺酸左氧氟沙星 光密度法 |
| 文章编号： | 1006-8147（2007）01-0093-03 |
| 收稿时间： | 2006-11-01 |
| 修稿时间： | 2006年11月1日 |
The comparison of postantibiotic effects induced by ciprofloxacin and levofloxacin in vitro |
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| XING Li,XU Lan.The comparison of postantibiotic effects induced by ciprofloxacin and levofloxacin in vitro[J].Journal of Tianjin Medical University,2007,13(1):93-95. |
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| Authors: | XING Li XU Lan |
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| Institution: | 1.Department of Obstetrics and Gynecology, Tianjin Central Hospital, Tianjin 300052, China;2.The Changzheng Hospital,Tianjin |
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| Abstract: | Objective: To compare the postantibiotic effects(PAEs)induced by ciprofloxacin and levofloxacin.Methods: PAEs were determined by the spectrophotometric method using AVANTAGE Microbiology System.Results: Ciprofloxacin and levofloxacin had significant PAEs against Gram-positive and Gram-negative bacteria,and the PAEs were both timeand concentration-dependant.The PAE of levofloxacin was longer than that of Ciprofloxacin against Staphylococcus aureus,Colibacillus,Pseudomonas aeruginosa.Conclusion: The rational prolongation of drug intervals is recommended according to the PAE of levofloxacin.The once daily levofloxacin dosing has better efficacy. |
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| Keywords: | Postantibiotic effects Levofloxacin Ciprofloxacin Spectrophotometric method |
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