Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells |
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Authors: | Mitsuru Yagi Takeshi Miyamoto Yoshiaki Toyama Toshio Suda |
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Institution: | (1) Department of Cell Differentiation, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;(2) Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan |
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Abstract: | Osteoclasts are the only cells that can resorb bone matrix physiologically and maintain the bone content. Osteoclasts are
derived from macrophage/monocyte lineage cells; stimulation by macrophage colony stimulating factor and receptor activator
of NFκB ligand induces osteoclastogenesis. During osteoclastogenesis, preosteoclasts fuse to form multinuclear mature osteoclasts.
Cellular fusion is a unique phenomenon and enables fertilization, myotube formation, and efficient bone resorption in vertebrates.
To date, several molecules have been reported to be fusion related in osteoclasts, namely CD44, CD47, ADAM12, MCP-1, and CD9,
although the molecules which regulate osteoclast cellular fusion remain unclear. Here, we show that the seven-transmembrane-region
receptor dendritic cell-specific transmembrane protein (DC-STAMP) is required for cell–cell fusion of osteoclasts and foreign
body giant cells. |
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Keywords: | osteoclast DC-STAMP fusion foreign body giant cell macrophage |
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