Combined renal replacement therapy for severe metformin-induced lactic acidosis.

Sir, This report is on a 68-year-old woman with a history of type2 diabetes mellitus treated with metformin 850 mg thrice daily,and mild chronic renal failure, who underwent cardiopulmonaryresuscitation for cardiovascular collapse because of severemetformin-associated lactic acidosis. Even after 12 h of continuousvenovenous