Microglia, but not astrocytes, react to sciatic nerve injury in aging rats |
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| Authors: | Shirley A Gilmore Cynthia JM Kane |
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| Institution: | Department of Anatomy-510, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA |
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| Abstract: | Peripheral nerve axotomy activates microglia and astrocytes within regions of brainstem or spinal cord from which the nerve arises. The present study demonstrates that unilateral sciatic axotomy in rats 2 to 18 months of age results in differing responses with age between these two glial populations. By 4 days postaxotomy, both astrocytes and microglia become activated in 2-month-old rats, whereas only the microglial population shows evidence of activation in rats 8 to 18 months of age. |
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| Keywords: | Astrocyte Microglia Sciatic nerve axotomy Glial fibrillary acidic protein |
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