中医药治疗乳腺增生病随机对照试验的Meta分析

目的系统评价中医药治疗乳腺增生的疗效和安全性。方法检索中医药治疗乳腺增生与三苯氧胺随机对照试验的文献进行Meta分析。结果符合纳入标准的论文共15篇,中医药治疗组与对照组相比,合并OR=2.36,95%置信区间(CI)为[1.89,2.95],对总体效应进行假设检验得Z值为7.56,P0.00001,两者差异有统计学意义(P0.00001);"漏斗图"图形显示存在发表性偏倚;中医药治疗组月经失调、胃肠道等不良反应明显低于对照组。结论现有临床证据表明中医药治疗乳腺增生可以提高临床疗效,且能明显减少不良反应发生率,但由于纳入研究质量所限,尚需开展更多高质量的研究进一步分析。

Traditional Chinese Medicine for Hyperplastic Disease of Breast:A Meta-analysis of Randomized Controlled Trials

Objective To systematically evaluate the curative effect and safety of traditional Chinese medicine （TCM） in the treatment of hyperplastic disease of breast （HDB）. Methods Searching randomized controlled trials of TCM and tamoxifen treatment on HDB, Meta-analysis were performed. Result Fifteen trials were included. Comparing TCM and tamoxifen （TAM）, Meta-analysis showed that the total odds ratio （OR）=2.36, 95% CI was [1.89, 2.95]. The difference had statistical significance between two groups （P〈 0.000 01）. Funnel plot graphics indicated publication bias. A lower incidence of menstrual disorder and gastrointestinal tract in TCM group. Conclusion The available data showed that the curative effect of TCM treatment of HDB is significant, and TCM treatment can reduce the incidence of side effects. Concerning the low-quality documents, more high-quailty researchs are needed in the future.