Ferret odor as a processive stress model in rats: neurochemical, behavioral, and endocrine evidence |
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Authors: | Masini C V Sauer S Campeau S |
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Institution: | Department of Psychology, University of Colorado, Boulder, CO 80309-0345, USA. masinic@psych.colorado.edu |
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Abstract: | Predator odors have been shown to elicit stress responses in rats. The present studies assessed the use of domestic ferret odor as a processive stress model. Plasma corticosterone and adrenocorticotropin hormone levels were higher after 30 min of exposure to ferret odor (fur/skin) but not control odors, ferret feces, urine, or anal gland secretions. Behavioral differences were also found between ferret and the control odors as tested in a defensive withdrawal paradigm. In addition, c-fos messenger RNA expression in several brain areas previously associated with processive stress was significantly higher in ferret odor-exposed rat brains than in control odor-exposed brains. These results suggest that ferret odor produces a reliable unconditioned stress response and may be useful as a processive stress model. |
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