国产氟康唑体外和体内抗真菌作用研究

国产氧康唑体外对２５株常见致病真菌以及体内对小鼠感染白念珠菌和新型隐球菌的抗菌作用与酮康唑和两性霉素Ｂ进行了比较。结果表明氟康唑在体外最小抑菌浓度（ＭＩＣ）不如其他两药。而口服氟康唑对感染小鼠的保护作用明显优于酮康唑和两性霉素Ｂ，口服治疗白念珠菌感染小鼠的５０％动物的有效浓度（ＥＢ５０）分别为０．８５ｍｇ／ｋｇ和３９．９８ｍｇ／ｋｇ，口服治疗新型隐球菌感染小鼠的ＥＤ５０分别为３．５４ｍｇ／ｋｇ和８１．６９ｍｇ／ｋｇ。

Study on Antifungal Activity of National Fluconazole in Vitro. and in Vivo

The antifungal activity of national fluconazole against 25 strains of common pathogenetic fungi in vitro and against Candida albicans and Cryptococcus neoformans experimental infection in mice was examined,compared with that of Ketoconazole and amphotericin B. The results indicated that minimal inhibitory concentration(MIC)of fluconazole was higher than that of other two drugs. The animal surviving to oral treatment with fluconazole was more active than ketoconazole against systemic infection with C. albicans or neoformans. The effective dose of 50% animal survivng (ED50) against C. albicans infection in mice to oral with fluconazole and ketoconazole was 0.85mg/kg and 39.98mg/kg separately. ED50 against C. neoformans infection in mice to oral with fluconazole and keto'conazole was 3.,54mg/kg and 81.69mg/kg separately.