| 吉西他滨单药治疗老年晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 方立萍,吴紫权,乔京京,赵金波. 吉西他滨单药治疗老年晚期非小细胞肺癌的临床观察[J]. 实用全科医学, 2010, 8(5): 562-562,611 |
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| 作者姓名： | 方立萍 吴紫权 乔京京 赵金波 |
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| 作者单位： | 方立萍,乔京京,赵金波(大连医科大学附属第二医院肿瘤内科,辽宁省大连市,116023);吴紫权(大连沙医生整形美容口腔专科医院) |
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| 摘 要： | 目的观察吉西他滨单药治疗老年晚期非小细胞肺癌（NSCLC）的临床疗效和毒性反应。方法38例Ⅲ～Ⅳ期NSCLC患者均经病理组织学或细胞学检查确诊。治疗剂量国产吉西他滨（泽菲）1000mg/m^2,静滴,第1,8天,每3～4周重复,2周期后CT评价疗效。结果38例患者均可评价,获得CR0例,PR10例,有效率26.3%（10/38）。中位疾病进展时间（TTP）为6.1个月,中位生存期6.9个月,1年生存率27.2%。主要的毒副反应为白细胞及血小板降低,均可耐受。结论吉西他滨单药治疗老年晚期NSCLC疗效确切,可明显改善患者生存质量，延长生存时间，副反应轻，顺应性好。
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| 关 键 词： | 非小细胞肺癌 吉西他滨 老年 化疗 |
Clinical Observation of Gemcitabine Monotherapy in the Treatment of Elder Patients with Advanced Non-small Cell Lung Cancer |
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| FANG Li-ping,WU Zi-quan,QIAO Jing-Jing,et al.. Clinical Observation of Gemcitabine Monotherapy in the Treatment of Elder Patients with Advanced Non-small Cell Lung Cancer[J]. Applied Journal Of General Practice, 2010, 8(5): 562-562,611 |
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| Authors: | FANG Li-ping WU Zi-quan QIAO Jing-Jing et al. |
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| Affiliation: | FANG Li-ping,WU Zi-quan,QIAO Jing-Jing,et al.Department of Oncology,the Second Affiliated Hospital of Dalian Medical University,Dalian 116023,Liaoning,China |
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| Abstract: | Objective To evaluate the clinical effect and toxicity of gemcitabine monotherapy in the treatment of elder patients with advanced non-small cell lung cancer(NSCLC).Methods 38 patients with advanced NSCLC diagnosed by pathology or cytology were enrolled into the study,The patients received GEM 1 000 mg/m2 on d1,d8,intravenously every 3-4 weeks and were evaluated effect after 2 cycles.Results Complete remisson(CR) was not observed and PR in 10 cases,the total response rate was 26.3%.The main side effects wer... |
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| Keywords: | Non-small cell lung cancer(NSCLC) Gemcitabine Elder patients Chemotherapy |
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