| 正己烷致大鼠脂质过氧化损伤的研究 |
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| 引用本文： | 沈齐英,刘录. 正己烷致大鼠脂质过氧化损伤的研究[J]. 环境与健康杂志, 2001, 18(2): 86-88 |
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| 作者姓名： | 沈齐英 刘录 |
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| 作者单位： | 北京石油化工学院 |
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| 摘 要： | 目的 探讨正己烷毒性的作用机制。方法 采用静式染毒方式连续 8h给 SD大鼠吸入正己烷 15 g/ m3。结果 大鼠全血 GSH含量明显降低 ,t- test P<0 .0 1;大鼠血清中 MDA含量虽有增多的趋势 ,但无统计学意义 (t- test P>0 .0 5 ;大鼠肝组织中 SOD和 GSH- Px活性明显降低 ,t- test P<0 .0 1。结论 正己烷可引起或增强机体氧自由基反应 ,导致脂质过氧化损伤 ,这可能是烷烃类物质对机体毒性作用机制之一。
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| 关 键 词： | 毒性 正己烷 脂质过氧化 谷胱甘肽过氧化物酶 超氧化物歧化酶 化学损伤 |
| 文章编号： | 1001-5914(2001)02-0086-03 |
| 修稿时间： | 2000-10-08 |
Study on n-Hexane-induced Lipid Peroxidative Injuries in Rats |
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| SHEN Qi-ying,LIU Lu. Study on n-Hexane-induced Lipid Peroxidative Injuries in Rats[J]. Journal of Environment and Health, 2001, 18(2): 86-88 |
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| Authors: | SHEN Qi-ying LIU Lu |
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| Abstract: | Objective To study the mechanism of toxicity of hexane Methods SD rats inhaled 15 g/m3 n hexane statically for 8 hours Results The levels of GSH in whole blood of rats declined significantly (t test,P<0 01) The levels of MDA in serum of rats revealed increasing trend but without statistical significance (t test,P?/40 05) The activities of SOD and GSH Px in liver of rats decreased significantly (t test,P<0 01). Conclusion n Hexane could induce or enhance the reaction of oxygen free radical in organism,and result in damages of lipid peroxidation,which might be one of the mechanisms of the toxicity of alkane |
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| Keywords: | n Hexane Lipid peroxidation Glutathione peroxidase Superoxide dismutase |
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