融斑通脉颗粒对家兔实验性高脂血症及动脉粥样硬化的影响

目的:探讨融斑通脉颗粒对家兔实验性高脂血症及动脉粥样硬化(AS)的影响。方法:将家兔分为正常对照组和高脂造模组,喂养至4周,将高脂造模组家兔分为高脂对照组、舒降之组和融斑通脉颗粒高、中、低剂量组,连续给药8周。于给药前、给药4周、给药8周测定血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平;实验结束后,取家兔主动脉和冠状动脉作病理学检查,并测定主动脉及肝脏组织脂质(TC、TG)含量。结果:与高脂对照组比较,融斑通脉颗粒组家兔血清TC、TG、LDL-C、VLDL-C浓度及TC/HDL-C比值明显降低(P<0.05~0.01),主动脉TC、TG含量及肝脏TC含量明显降低(P<0.05);病理分析显示,融斑通脉颗粒组家兔主动脉斑块面积、厚度、泡沫细胞形成数量及反映冠状动脉管腔狭窄程度的平均得分均明显减少(P<0.05~0.01)。结论:融斑通脉颗粒具有调节血脂、防治AS的作用。

Effect of Rongban Tongmai Granules on experimental hyperlipidemia and atherosclerosis in rabbits

AIM: To study the effect of Rongban Tongmai Granules on hyperlipidemia and atheriosclerosis in rabbits. METHODS: The model of experimental atherosclerosis was prepared by feeding high cholesterol and lipid diet for weeks.After 4 weeks,hyperlipidemic rabbits were randomly divided into five groups,model group,high,medium and low doses of Rongban Tongmai Granules and Shujiangzhi group,taking medicine for 8 weeks.Their blood lipid levels(TC,TG,LDL-C,HDL-C,VLDL-C and TC/HDL-C) were measured before experiment,after treatment,for 4 weeks and for 8 weeks.After having been treated for 8weeks,lipid levels in aortic tissue and liver tissue were estimated,and pathologic changes in aortic and coronary arteries were also observed. RESULTS: The medicine could decrease TC,TG,LDL-C,VLDL-C and TC/HDL-C in serum,TC in liver tissue,and TC,TG in aorta tissue of atherosclerotic rabbits.It could also reduce aortic atherosclerotic plaque coverage of aortic initial surface,initial thickness,foam cells,and the average score representing the degree of coronary arteries stenosis. CONCLUSION: Rongban Tongmai Granules can lower lipid level in serum and related tissue,and prevent the formation of atherosclerosis.