奥沙利铂联合氟脲嘧啶治疗晚期胃癌42例临床观察

目的观察奥沙利铂（L-OHP）联合氟脲嘧啶（5一-FU）治疗晚期胃癌近期疗效及不良反应。方法42例晚期胃癌患者，初治20例，复治22例。L-OHP135mg／m^2静滴d1，亚叶酸钙（CF）0．2g静滴d1．5，5-FU500mg／m^2持续静滴d1-5，21d为1周期，每例化疗3～4个周期。结果化疗总有效率59．5％（25／42）、PR24例、CR1例。初治病例有效率65％（13／20），复治病例有效率40．9％（9／22）。结论奥沙利铂联合氟脲嘧啶治疗晚期胃癌疗效较好，毒副反应可以耐受。

Oxaliplatin Combined with 5-Fluorouracil for Advanced Gastric Carcinoma:a Report of 42 Cases

Objective To evaluate the short term activity and toxicity of chemotherapy of Oxaliplatin （L-OHP） combined with 5-Fluorouraeil （5-FU） for advanced gastric carcinoma. Methods Forty two cases with advanced gastric cancer （including 20 cases of initial treatment and 22 cases of recurrent） were treated with L-OHP, calcium folinate （CF） ,5-FU 500,ivgtt, d1-5. Cycles repeated every 21 days, and 3 - 4 cycles were delivered for each patient. Results The overall effective rate was 59.5% （25/ 42 ）. The effective rate for initial cases and recurrent cases were 65 % （ 13/20 ） and 40.9% （9/22） respectively. Conclusions Oxaliplatin combined with 5-Fluorouracil/CF has a good tolerance and efficacy for advanced gastric cancer.