男性寻常痤疮患者膳食生糖负荷水平与皮损严重程度的相关性研究

目的探讨男性寻常痤疮患者膳食生糖负荷水平与皮损严重程度间的相关性,分析膳食结构对寻常痤疮的影响及其在发病机制中的作用。方法使用24 h膳食回顾问卷（24-HDR）及食物频率调查问卷（FFQ）调查200例男性寻常痤疮患者膳食生糖负荷水平,以寻常痤疮综合分级系统（GAGS）评价皮损严重程度。结果 GAGS评分1~18分者占31.00%,19~30分者占28.50%,31~38分者占26.50%,≥39分者占14.00%;病程〉6个月者皮损严重程度明显高于≤6个月者,差异具有统计学意义（P〈0.05）;病程≤6个月者膳食生糖水平为（243.85±54.74）,〉6个月者为（310.12±123.56）,不同病程的患者膳食生糖负荷水平比较差异具有统计学意义（P〈0.05）;GAGS评分1~18分者膳食生糖负荷水平为（184.22±38.61）,19~30分者为（289.64±70.34）,31~38分者为（362.57±92.83）,≥39分者为（420.48±98.69）,不同GAGS评分患者膳食生糖负荷水平之间比较差异具有统计学意义（P〈0.05）;不同GAGS评分患者膳食生糖负荷水平进行两两t检验,各组间比较差异均具有统计学意义（P〈0.05）;患者膳食生糖负荷水平与患者皮损严重程度直线相关分析两者之间呈弱正相关（r=0.38,P〈0.05）。结论寻常痤疮膳食生糖负荷水平与患者皮损严重程度密切相关,高膳食生糖负荷水平可能是引起患者发病及病情加重的原因之一。

Correlation of dietary raw sugar load levels and the severity of lesions in male patients with acne vulgaris.

Objective To investigate the correlation of dietary raw sugar load levels with the severity of skin lesions in male patients with acne vulgaris, and to analyze the effect of meal structure on acne vulgaris and its role in the pathogenesis. Methods Using 24 hour dietary recalls questionnaire （24-HDR） and food frequency questionnaire （FFQ）, 200 male patients with acne vulgaris were surveyed for dietary raw sugar load levels Comprehensive grading system （GAGS） was applied to evaluate the severity of lesions. Results Patients with GAGS score of 1-18 points ac- counted for 31.00%, 19-30 points for 28.50%, 31-38 points for 26.50%, and ~〉39 points for 14.00%. The patients with disease duration〉6 months had significantly higher severity of lesions than those with disease durations〈6 months （P〈0.05）. The dietary raw sugar load level was （243.85q-54.74） for patients with disease duration---〈6 months and （310.12 ~ 123.56） for patients with disease duration〉6 months, showing statistically significant difference （P〈 0.05）. The dietary raw sugar load level was （184.22=t=38.61） for patients with GAGS score of 1-18 points, （289.64q- 70.34） for patients with GAGS score of 19-30, （362.57=t=92.83） for 31-38 points, and （420.48~98.69） for I〉39 points, with statistically significant difference （P〈0.05）, There was a weak positive correlation between the dietary raw sugar load level in patients with lesions and the severity of lesions （~-0.38, P〈0.05）. Conclusion Dietary raw sugar load levels and severity of skin lesions of patients are closely related, and high dietary levels of raw sugar load may cause the development and exacerbations of acne vulgaris.