SonoVue超声造影评价慢性移植肾功能不全的临床研究

目的利用SonoVue超声造影技术对移植肾肾皮质微循环血流灌注进行观测,分析该技术在慢性移植肾功能不全评价方面的临床价值。方法同种异体移植肾患者60例,男性38例,女性22例,移植术后时间大于6个月。肾功能正常组30例,慢性肾功能不全组30例。选择仪器为SIEMENS公司Sequoia512彩色多普勒超声诊断仪,配备造影成像技术;造影剂为SonoVue（Bracco,Italy）,患者取平卧位,常规超声检查结束后启动超声造影模式,持续观察并实时存储图像,回放图像进行分析。主要观测指标包括：造影剂开始灌注的时间（ST）、造影剂灌注的达峰时间（PT）、造影剂灌注时间（T）、回声峰值强度（PI）。结果 60例移植肾患者超声造影图像均符合分析标准。慢性肾功能不全组与肾功能正常组之间的超声造影观测指标（PT、T、PI）差异有统计学意义（P〈0.05）。结论 SonoVue超声造影成像可以监测慢性移植肾功能不全肾皮质微循环血流灌注的异常,且临床价值优于二维超声。

Clinical value of SonoVue contrast-enhanced ultrasonography in the evaluation of chronic renal insufficiency.

Objective To research the clinical value of SonoVue contrast-enhanced uhrasonography in the eval- uation of patients with chronic renal insufficiency. Methods Sixty patients with renal allograR, including 38 males and 22 females, were enrolled into this study, which were divided into the control group （n=30, with normal renal function） and the study group （n=30, with chronic renal insufficiency）. Time after transplantation in all the patients was more than six months. Sequoia512 （SIEMENS, Mountain View） equipped with contrast software of contrast pulsed sequences were used, with ultrasound contrast agent of SonoVue （Bracco, Italy）. Patients were placed as supine position, and subsequently evalu- ated by SonoVue ultrasound contrast imaging after conventional ultrasound imaging. The images were stored real-timely and analyzed by review. The main outcome measuring indicators included the time of agent starting perfusing （ST）, time of agent perfuming arriving peak value （PT）, time of agent perfuming （T） and were echo peak intensity （PI）. Results All the 60 patients were successfully examined with ultrasound contrast imaging. All images of ultrasound contrast were in line with the analysis standard. The indicators （PT, T, PI） were significantly different between the two groups （P〈0.05）. Conclusion Renal graR cortex mierocirculation perfusion changes of chronic renal insufficiency can be monitored by So- noVue contrast ultrasound imaging, and its clinical value is superior to two-dimensional ultrasoungraph.