病毒逃避细胞毒性T细胞免疫研究进展

病毒感染期间,病毒与宿主免疫系统之间发生一系列复杂的互相作用,宿主的目的是清除感染及将病理影响减少至最低限度;而病毒则试图逃避清除,以便长期存在及播散至其他宿主.细胞介导的免疫反应特别是病毒特异性CD8细胞毒T细胞(cytotoxicTlymphocyte,CTL)反应,常常在清除病毒感染中起关键作用,故许多病毒的逃避策略即针对于此.在感染过程中,病毒蛋白上氨基酸改变可影响CTL对其表位的识别,而这种逃避机制在病毒感染过程中可引起发病/病情迁延.

Advances on study on virus escape from the immune response of cytotoxic T lymphocyte

Following virus infection, a series of complex interactions occur between the virus and the host immune system. The host aims to eliminate the infection and minimize associated pathological consequences, whilst the virus tries to avoid clearance by the host immune response so that it can persist and be disseminated to other hosts over a long time period. As cell_mediatd immune responses, in particular the virus_specific CD8 +cytotoxic T lymphocyte (CTL) response, frequently play a key role in the eliminatin of established virus infections, many viral evasion strategies are targeted to this arm of the immune response. The mechanisms by which amino acid change in viral proteins may affect epitope recognition by virus_specific CTL are described. This escape mechanism that may contribute to persistence/pathogenesis in different virus infections is discussed.