高刺激速率听性脑干反应实验室正常参考值研究*

目的获得正常青年的高刺激速率(high stimulus rate)听性脑干反应(ABR)实验室正常参考值范围并分析其特点,为诊断后循环缺血提供参考依据.方法对20例听力正常青年(男女各10例,共40耳)分别进行刺激速率为11.1次/s和51.1次/s的ABR检测,比较两种不同刺激速率下I、III、V波的潜伏期(peak latency,PL),I~III、III~V、I~V波间期(inter-peak latency,IPL)和波间期的差值(ΔIPL),并对测试的结果进行统计分析.结果刺激速率为11.1次/s时波I、III、V的PL分别为1.33±0.07、3.57±0.18、5.51±0.23 ms;I~III、III~V、I~V的IPL分别为2.25±0.19、1.93±0.16、4.18±0.21 ms.刺激速率为51.1次/s时波I、III、V的PL分别为1.44±0.06、3.74±0.16、5.80±0.18 ms;I~III、III~V、I~V的IPL分别为2.31±0.14、2.06±0.12、4.36±0.17 ms.高低刺激速率下I~III、III~V、I~V的ΔIPL分别为0.06±0.08、0.13±0.10、0.18±0.09 ms.不同刺激速率下I~V的ΔIPL实验室正常参考值范围为△I~V<0.328 ms.结论随刺激声速率升高,ABR各波PL、IPL、ΔIPL均会延长.本文提出了听力正常的青年人不同刺激速率下ABR各波潜伏期、波间期和I~V波间期差值的实验室正常参考值范围,为后循环缺血患者的早期诊断提供参考依据.

The Normal Laboratory Reference Values of the Auditory Brainstem Responses at High Stimulus Rates

Objective To obtain the normal laboratory reference values of auditory brainstem response（ABR） recorded at high stimulus rates in normal-hearing young subjects and to analyze the characteristics, in order to provide the basis for the diagnosis of posterior circulation ischemia. Methods Twenty normal-hearing young adults （10 males and 10 females, 40 ears） received the ABR test with the stimulus rate at 11.1/s and 51.1/s respectively. The peak latencies （PL） of I, III, and V, inter-peak latencies（IPL） of I-III, III-V and I-V and inter-peak latency differences （△IPL） were compared between low and high stimulus rate and statistically analyzed. Results For the ABR recorded at 11.1/s, the peak latencies of I, III, V were 1.33 ±0.07, 3.57±0.18, 5.51±0.23 ms respectively; inter-peak latencies of I-III, III-V, I-V were 2.25±0.19, 1.93±0.16, 4.18±0.21 ms respectively. For the ABR recorded at 51.1/s, the peak latencies of I, III, and V were 1.44±0.06, 3.74±0.16, and 5.80±0.18 ms respectively; inter-peak latencies of I-III, III-V, and I-V were 2.31±0.14, 2.06±0.12 and 4.36±0.17 ms respectively. The inter-peak latency differences of I-III, III-V, and I-V between high and low-stimulus-rate ABR were 0.06±0.08, 0.13±0.10 and 0.18±0.09 ms respectively. The normal laboratory reference value of △IPL（△I-V） was no more than 0.328 ms. Conclusion The PL,IPLand△IPL of the ABR waveforms can be prolonged with the increasing stimulus rate. This article provides the normal reference ranges of PL, IPL and △IPL for ABR waveforms under different stimulus rates in normal-hearing young subjects, which may facilitate the early diagnosis of the posterior circulation ischemia.