阿维A与MTX治疗泛发性脓疱型银屑病的疗效比较

目的　比较阿维A与MTX治疗泛发性脓疱型银屑病的疗效。方法　回顾调查我科自 1995年～ 2 0 0 1年的泛发性脓疱型银屑病的住院病历 ,其中糖皮质激素合用MTX治疗的病例 2 0例 ,糖皮质激素合用阿维A治疗的病例10例。用t检验比较发热、红斑和脓疱的平均消退时间 ,χ2 检验随访 1个月的复发率。结果　发热、脓疱的平均消退时间差异无显著性 (P >0 .0 5 ) ,红斑平均消退时间差异有显著性 (P <0 .0 5 ) ,阿维A组优于MTX组 ;两组复发率比较差异无显著性 (P >0 .0 5 )。结论　在泛发性脓疱型银屑病的系统治疗中 ,糖皮质激素合用阿维A的疗效优于糖皮质激素合用MTX的疗效。

Comparison of the Efficacy of Acitretin and MTX on Treating Generalized Pustular Psoriasis

Objective To compare the efficacy of acitretin and MTX in generalized pustular psoriasis(GPP) treatment.Methods All the in-patient cases of GPP from January of 1995 to October of 2001 were studied retrospectively,including 10 cases treated with Acitretin plus corticosteroids,20 cases treated with MTX plus corticosteroids.The average disappearance times of fever,erythema and pustules were compared with t-test.Recurrence rate was compared with χ 2-test.Results The average disappearance times of fever or pustules had no significant statistical difference (P>0.05), on the contrary,those of erythema had significant statistical difference(P<0.05),and Acitretin group was superior to MTX group;the recurrence rates had no significant difference,either.Conclusion In the systematic treatment of GPP,Acitretin is superior to MTX in efficacy.