| 可溶性细胞间粘附分子-1在急性冠脉综合征中的意义 |
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| 引用本文： | 赵玉兰,杨素霞. 可溶性细胞间粘附分子-1在急性冠脉综合征中的意义[J]. 医药论坛杂志, 2006, 27(5): 25-26 |
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| 作者姓名： | 赵玉兰 杨素霞 |
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| 作者单位： | 郑州大学第二附属医院心内科,郑州市,450014 |
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| 摘 要： | 目的检测急性冠脉综合征患者外周血清可溶性细胞间粘附分子-1(sICAM-1)的变化,探讨炎症标记物与急性冠脉综合征的关系及临床意义。方法选择急性冠脉综合征患者40例,稳定型心绞痛20例及正常对照组20例,所有样本均于入院第2d清晨抽取肘静脉血3m l,ELISA法测定血清可溶性细胞间粘附分子-1的变化。结果急性冠脉综合征组与稳定型心绞痛组和正常对照组比较,血清sICAM-1均显著增高(P<0.05)。结论炎症参与了急性冠脉综合征的发病机制,血清中sICAM-1水平的高低与病情严重程度有关,提示sICAM-1与不稳定粥样斑块破裂密切相关,可作为筛查ACS患者的一个炎症指标。
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| 关 键 词： | 急性冠脉综合征 稳定型心绞痛 |
| 文章编号： | 1672-3422(2006)05-0025-02 |
| 收稿时间： | 2005-11-21 |
| 修稿时间： | 2005-11-21 |
Clinical Significance of Serum Soluable Intercellur Adhension Molecule - 1 in Acute Coronary Syndrome |
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| ZHAO Yulan,YANG Suxia. Clinical Significance of Serum Soluable Intercellur Adhension Molecule - 1 in Acute Coronary Syndrome[J]. Journal of Medical Forum, 2006, 27(5): 25-26 |
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| Authors: | ZHAO Yulan YANG Suxia |
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| Affiliation: | Department of Cardiology, the Second Affilated Hospital, Zhengzhou University Zhengzhou 450014, China |
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| Abstract: | Objective To investigate the relation of soluable intercellur adhension molecule-1(sICAM-1) to acute coronary syndrome.Methods 40 patients were selected as acute coronary syndrome(ACS)group,20 patients with stable angina pectoris(SAP) and 20 patients as control group.The blood samples are drawan from venous in the morning of the 2nd day.The concentration of soluable intercellur adhension molecule-1(sICAM-1) was determined by ELISA.Results ACS vs SAP,ACS vs control,SAP vs control,the levels sICAM-1 raise significantly(P<0.01).Conclusion sICAM-1 may be involved in the pathgenesis of ACS,it has close relations with the rupture of the unstable atheromatous plaques. |
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| Keywords: | sICAM-1 |
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