煤烟对机体抗氧化系统功能影响的干预研究

目的通过研究不同种类的燃煤煤烟对机体抗氧化系统功能的影响,探讨不同种类的燃煤对人群健康的作用。方法选择重庆市郊某乡村以普通煤为生活燃料的家庭主妇进行人群干预试验,其中干预组改用固硫煤作燃料,对照组仍用普通煤。两组均检测干预前、中、末3个时期人体外周血中的丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)的含量。结果试验末,干预组MDA由干预前的3.43 nmol/L降为干预18个月时的2.44 nmol/L,显著低于干预前,也显著低于对照组。干预组GSH-Px和SOD在干预期间无显著变化。Hotelling-T2检验结果显示,干预组的抗氧化系统功能与干预前相比,差异有统计学意义。结论用固硫型煤代替普通原煤作为生活燃料,可减少机体的氧化损伤,对维护人体的健康有积极的作用。

Intervention Research on Effects of Coal Smoke on Anti-oxidation System Function

Objective Through the study on effects of coal smoke from different species of fuel coal on anti-oxidation system function,to explore their effects on the health of population.Methods Housewives,living in two villages near suburban area of Chongqing city and using raw coal as the cooking fuel,were chosen to conduct the community intervention experiment.The intervention group altered the fuel to biomass briquette,while the control group didn't.The contents of malonaldehyde(MDA),glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)in peripheral blood were measured at the beginning,middle and the end of the intervention.Results After intervention,MDA of the intervention group decreased from 3.43 nmol/L to 2.44 nmol/L(18 months after intervention),significantly lowered than before and that of the control group.GSH-Px and SOD of the intervention group showed no significant change during the intervention period.Result of Hotelling-T2 test showed that the function of antioxidation system of the intervention group was significantly different from that before the experiment.Conclusions Briquette,used as cooking fuel substitute,could reduce the oxidation damage of people.It is positive in health promotion.