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Effect of transient forebrain ischemia on superoxide dismutases in gerbil hippocampus |
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| Authors: | Toshiho Ohtsuki Masayasu Matsumoto Keiichiro Suzuki Naoyuki Taniguchi Takenobu Kamada |
| Affiliation: | aFirst Department of Internal Medicine, Osaka University Medical School, Osaka, Japan bDepartment of Biochemistry, Osaka University Medical School, Osaka, Japan |
| Abstract: | Substantial generation of oxygen-derived free radicals has been implicated in pathophysiology of ischemic brain damage. Immunoreactive mitochondrial manganese and cytosolic copper-zinc superoxide dismutases, initial and essential enzymes to scavenge superoxide radical anions, increased in the gerbil hippocampal neurons after transient forebrain ischemia. Neuronal cells responded to oxidative stress in ischemia and induced the protective mechanism to increase superoxide dismutases. |
| Keywords: | Transient forebrain ischemia Manganese superoxide dismutase Copper-zinc superoxide dismutase Hippocampus Ischemic tolerance Gerbil |
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