The combined analysis of P-glycoprotein expression and activity predicts outcome in childhood acute lymphoblastic leukemia |
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| Authors: | De Moerloose Barbara Swerts Katrien Benoit Yves Laureys Geneviève Loeys Tom Philippé Jan Dhooge Catharina |
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| Affiliation: | a Department of Pediatrics, Ghent University Hospital, Ghent, Belgium.b Department of Applied Mathematics and Computer Science, Ghent University, Ghent, Belgium.c Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium. |
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| Abstract: | The link between drug resistance and relapse was often suggested, but rarely demonstrated in long-range clinical studies. Since it is nowadays recommended to validate immunocytochemical results, the authors studied prospectively 52 acute lymphoblastic leukemia (ALL) patients with an immunocytochemical test and a functional flow cytometric test. The 4-year EFS and OS were 79.3% and 85.2%, respectively. Patients scoring positive in both tests had a significantly higher relapse rate and worse survival (log rank p = .007 and .047 for event-free survival and overall survival, respectively). Among the different prognostic variables evaluated, only the combination of P-gp expression and activity was a statistically significant parameter predicting relapse in childhood ALL. |
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| Keywords: | Childhood Acute Lymphoblastic Leukemia Flow Cytometry Immunocytochemistry Multidrug Resistance P-glycoprotein |
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