| 血管内皮生长因子在子宫内膜异位症中的表达及意义 |
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| 引用本文： | 齐璇,辛晓燕,常吉庆,王德堂,郭会玲.血管内皮生长因子在子宫内膜异位症中的表达及意义[J].医学研究生学报,2003,16(3):180-181,184,F002. |
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| 作者姓名： | 齐璇 辛晓燕 常吉庆 王德堂 郭会玲 |
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| 作者单位： | 1. 第四军医大学西京医院妇产科,陕西西安,710032
2. 第四军医大学西京医院病理科,陕西西安,710032 |
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| 摘 要： | 目的：探讨血管内皮生长因子(VEGF)在子宫内膜异位症发生、发展中的作用。方法：应用免疫组织化学(SABC)法，检测70例异位内膜组织和30例正常子宫内膜组织(对照组)中VEGF的表达。结果：VEGF在异位内膜组织及对照组中的阳性表达率分别为77．14％和43．33％(P＜0．001)，强阳性表达率分别为25．71％和3．3％(P＜0．01)。而VEGF在卵巢子宫内膜异位症组和子宫腺肌症组中的阳性表达率分别为77．78％和76．47％(P＞0．05)。结论：异位内膜组织中VEGF的过度表达与异位内膜组织的血管生成密切相关，VEGF在子宫内膜异位症的发生发展中发挥作用。
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| 关 键 词： | 子宫内膜异位症 血管生成 血管内皮生长因子 |
| 文章编号： | 1008-8199(2003)03-0180-02 |
Expression and significance of VEGF in endometriosis |
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| QI Xuan ,XIN Xiao yan ,CHANG Ji qing ,WANG De tang ,GUO Hui ling.Expression and significance of VEGF in endometriosis[J].Bulletin of Medical Postgraduate,2003,16(3):180-181,184,F002. |
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| Authors: | QI Xuan XIN Xiao yan CHANG Ji qing WANG De tang GUO Hui ling |
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| Institution: | QI Xuan 1,XIN Xiao yan 1,CHANG Ji qing 2,WANG De tang 1,GUO Hui ling 1 |
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| Abstract: | Objectvies:To investigate the role of vascular endothelial growth factor(VEGF) in the pathogenesis of endometriosis(EMs). Methods:A total of 70 specimens of endometriosis and 30 specimens of the normal controls were evaluated by immunohistologically techique with polyclonal antibody against VEGF. Results:The expression levels of VEGF in endometriotic tissues was higher than that in the normal endometrium( P <0.001). Conclusions:VEGF was overexpressed in endometriotic tissues.There was closed relationships between VEGF and endometriosis angiogenesis.VEGF played an important role in the progression of endometriosis. |
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| Keywords: | Endometiosis Angiogenesis Vascular endothelial growed factor |
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