Osteogenic sarcoma and androgens |
| |
| Authors: | N. N. Trapeznikov N. E. Kushlinskii Yu. N. Solov'ev M. D. Aliev |
| |
| Affiliation: | (1) Laboratory of Clinical Biochemistry, Surgery Department of General Oncology, Department of Pathological Anatomy of Human Tumors, Institute of Clinical Oncology, N. N. Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow |
| |
| Abstract: | Endocrinologic examination of 320 male patients with primary osteogenic sarcoma reveals predominance of hyperandrogenemia characterized by decreased levels of sex hormonebinding globulin, elevated testosterone concentration, and increased free androgen index. The occurrence of androgen receptors was similar in the cytosolic fraction of osteogenic sarcoma (56%), benign tumors and tumor-like bone lesions (50%), while their content was higher in osteogenic sarcoma, implying an unfavorable prognosis of metastasizing. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122 No. 9, pp. 305–310, September, 1996 |
| |
| Keywords: | osteogenic sarcoma testosterone androgen receptors sex hormone-binding globulin |
| 本文献已被 SpringerLink 等数据库收录！ |
|
