Primary Cutaneous Amyloidosis: Identically Distributed Lesions in Identical Twins |
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| Authors: | Philip E LeBoit MD Ira Greene MD |
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| Institution: | Departments of Pathology and Dermatology, University of California, San Francisco;Department of Dermatology, Stanford University, Stanford, California |
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| Abstract: | Male HLA-identical twins with numerous congenital abnormalities were discovered to have lichen amyloidosus in similar distribution on their chests and abdomens. Pruritus was absent in both. The finding of identical distribution of nonpruritic lesions was previously reported in familial lichen amyloidosus. This suggests that a subset of these patients have a nevoid condition in which a circumscribed patch of keratinocytes undergoes filamentous degeneration and may appear in identical distribution in family members in the absence of pruritus. |
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