正常家兔胃饲不同剂量中药大黄前后的血液流变学观察

本文通过动物实验,比较研究了不同剂量大黄(即临床治疗剂量3g 和超临床剂量6g)的血液流变学作用。结果表明,临床治疗剂量引起以血液粘度降低为主的双相变化,而超临床治疗剂量则引起血液粘度的显著增高。在上述两种情况下,血浆渗透压均表现为明显增高,提示不同剂量大黄所引起的血液粘度降低和增高的双相变化可能是由于血浆渗透压增高具有抗利尿和利尿两种不同的水代谢调节作用所致。

The Effect of Rheum Palmatum in Different Doses on Blood Rheology in Rabbits

In the present paper,the results of a study on the hemorheological effect of Rheum palmatum L,a Chinese drug,in different doses on rabbits are reported.Hemorheology tests were carried out before and after administration of the drug to check changes in hematocrit,whole blood viscosity,plasma viscosity, electrophoretic time of erythrocytes in their own plasma and plasma osmotic pressure.The rabbits used in the experiments were divided into two testing groups.In group A,it was observed that 4 hours after administration in dose of 3 g,there appeared a diphase effect of the drug on viscosity and hematocrit accompanied by an uniform increase in plasma osmotic pressure.In group B of rabbits,to which the drugs in dose of 6 g were administrated,the testing data showed that a change with time took place.Blood viscosity,hematocrit,electrophoretic time and plasma osmotic pressure were found lower than normal at first(within 2 hours),and then went up to higher level.It seems that the diphase changes in the two cases are caused by the increase of plasma osmotic pressure through adjusting the balance between diuresis and anti-diuresis.