| 葡萄糖氯化钠钾注射液与甲硝唑注射液、替硝唑葡萄糖注射液配伍的稳定性 |
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| 引用本文： | 马爱玲,陈晓辉,魏京海,毕开顺. 葡萄糖氯化钠钾注射液与甲硝唑注射液、替硝唑葡萄糖注射液配伍的稳定性[J]. 中国实用医药, 2008, 3(13): 26-27 |
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| 作者姓名： | 马爱玲 陈晓辉 魏京海 毕开顺 |
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| 作者单位： | 1. 沈阳药科大学药物分析教研室,110016
2. 北京,首都医科大学附属北京儿童医院药剂科 |
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| 摘 要： | 目的研究在室温下葡萄糖氯化钠钾注射液（简称GNK）分别与甲硝唑注射液、替硝唑葡萄糖注射液配伍后的稳定性。方法采用RP—HPLC法分别测定配伍后甲硝唑和替硝唑的含量变化，同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8h内均无气体或沉淀产生，pH值、不溶性微粒和含量均无明显变化。结论GNK与甲硝唑注射液、替硝唑葡萄糖注射液配伍后8h稳定，在8h内可安全应用于临床。
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| 关 键 词： | 配伍稳定性 葡萄糖氯化钠钾注射液 甲硝唑 替硝唑 |
Compatible stabilities of glucose and sodium chloride potassium chloride injection mixing with metronidazole and tinidazole for injection |
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| MA Ai-ling,CHEN Xiao-hui,WEI Jing-hai,et al.. Compatible stabilities of glucose and sodium chloride potassium chloride injection mixing with metronidazole and tinidazole for injection[J]. China Practical Medical, 2008, 3(13): 26-27 |
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| Authors: | MA Ai-ling CHEN Xiao-hui WEI Jing-hai et al. |
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| Affiliation: | MA Ai-ling,CHEN Xiao-hui,WEI Jing-hai,et al.Department of Pharmaceutical Analysis,Shenyang Pharmaceutical University,Shenyang 110016,China |
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| Abstract: | Objective To observe the stabilities of glucose and sodium chloride potassium injection （GNK） mixing with metronidazole and tinidazole at 25℃. Methods RP-HPLC was applied to determine the content changing of metronidazole and tinidazole in different time. The pH, quantity of non-soluble particulate and appearance of mixtures were also observed. Results In room temperature the mixtures produced neither gas nor sediment. The pH,quantity of non-soluble particulate and content did not change within 8 hours. Conclusion The mixtures of GNK mixing with metronidazole and tinidazole were stable in 8 hours. |
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| Keywords: | Compatible stabilities GNK Metronidazole Tinidazole |
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